18 October1503 of blood poisoning from an ulcer on his leg at Rome, Italy;
rumours of poisoning began immediately upon his death;
buried in Saint Peter's Basilica;
remains later transferred to San Andrea della Valle and interred beside PopePius II
[H]e left no moment unoccupied; his time for study was before daybreak; he spent his mornings in prayer and his midday hours in giving audiences, to which the humblest had easy access.
He was so temperate in food and drink that he only allowed himself an evening meal every other day.