Son of the pious Florentius Dedel, who died when his son was very young.
Adrian taughtphilosophy at Louvain.
Dean of the collegiate church, and later vice-chancellor.
In 1506 he became tutor of the young prince who would later be the Holy Roman Emperor Charles V.
Regent of Spain in 1520.
The ascetic and pious Adrian found a Vatican where Roman life was extravagant, papal expenditures lavish, and the Curia in need of reform.
He did his best to curb these abuses, and to stir Christians to oppose the advancing Turks, but he died after only 20 months.