Time Line 1521
- death of Blessed Calimerius of Montechiaro
- death of Blessed Dominic Spadafora
- death of Blessed Margaret of Lorraine
- death of Pope Leo X
- Pope Leo X names King Henry VIII Defender of the Faith
- birth of Saint Andrew Avellino
- birth of Saint Peter Canisius
- birth of Pope Sixtus V
- birth of Pope Urban VII
- founding of the Anabaptists
| 1520 | 1522 |
